The co-occurrence of stress-induced posttraumatic stress disorder and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understanding of the pathways connecting stress to PTSD and obesity is focused largely on behavioral mediators alone with little consideration of the biological regulatory mechanisms that underlie their co-occurrence. In this work, we leverage prior knowledge to systematically (...) highlight such bio-behavioral mechanisms and inform on the design of confirmatory pilot studies. We use natural language processing to extract documented regulatory interactions involved in the metabolic response to stress and its impact on obesity and PTSD from over 8 million peer-reviewed papers. The resulting network describes the propagation of stress to PTSD and obesity through 34 metabolic mediators using 302 documented regulatory interactions supported by over 10,000 citations. Stress jointly affected both conditions through 21 distinct pathways involving only two intermediate metabolic mediators out of a total of 76 available paths through this network. Moreover, oxytocin, Neuropeptide-Y, and cortisol supported an almost direct propagation of stress to PTSD and obesity with different net effects. Although stress upregulated both NPY and cortisol, the downstream effects of both markers are reported to relieve PTSD severity but exacerbate obesity. The stress-mediated release of oxytocin, however, was found to concurrently downregulate the severity of both conditions. These findings highlight how a network-informed approach that leverages prior knowledge might be used effectively in identifying key mediators like OXT though experimental verification of signal transmission dynamics through each path will be needed to determine the actual likelihood and extent of each marker’s participation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Spatializing Culture: The Ethnography of Space and Place by Setha LowCarlos J. L. BalsasSpatializing Culture: The Ethnography of Space and Placeby setha low London: Routledge, 2017Spatializing Culture: The Ethnography of Space and Place adds clarity to our understanding of the value of ethnographic scholarship in the study of socio-economic, cultural, and developmental transformations. The book is a thorough review of two established conceptual frames of analysis—the social production (...) of space and the social construction of space—coupled with an in-depth discussion of four newer ways to make sense of the world around us: embodied space, language and discourse, emotion and affect, and translocal space. As the world is transformed by a myriad of forces and events occurring simultaneously, its complexity intensifies insurmountably and we require clear and robust concepts, theories, methods, and tools to not only interpret it, but above all to attempt to change it in ways that are more beneficial to our collective co-existence while enabling the flourishing of those most at risk.Readers of Spatializing Culture will find plentiful theoretical constructs, lineages, diverse viewpoints, examples, and overall opportunities for reflecting on how the (built) environment, spaces, and places have been changing mostly due to our behavior. Inspired by Foucault’s take on genealogy, in chapter 2, Setha Low traces the history of space and place according to distinct interpretative schools of thought ranging from philosophical and mathematical, French social theory, geographical, architectural, environmental psychology, to anthropological, and even archeological. Five Venn diagrams are utilized to illustrate the main conceptual relationships between space and place. Most of the book’s in-depth case studies were researched by the author with only a small number investigated and written up by fellow scholars, which Low utilizes in the book with gratitude. The interrelated thematic and distinct geographical scope of the cases is one of the book’s hallmarks. The illustrative case studies come from such faraway places as Latin America (San José, Costa Rica), Asia (Taipei, Taiwan), North America (New York City; Washington, D.C.; Philadelphia, Pennsylvania; and San [End Page 151] Antonio, Texas), Southern Europe (Smederevska Palanka, Serbia), and the Middle East (Beirut, Lebanon; Cairo, Egypt; and Tel Aviv, Israel).Spatializing Culture was first mentioned to me years ago by a former colleague at the University at Albany, SUNY. His ongoing work in Latin America, coupled with his ethnographic training and prior work in a region of the world also extensively examined by Low in other scholarly works, was likely the reason for bringing it up in a conversation about the latest developments in the field and potential research opportunities. I acquired the book when I was teaching Global Urbanism and Culture and International Urban Planning. I was pleasantly surprised with the book’s thorough conceptual lineage, historic characterizations, attention to detail, comprehensive ethnographic investigations, and implications for transforming reality as well as institutional processes. Spatializing Culture is a welcome addition to urban planning textbooks, which tend to be relatively less critical, are often covered with normative constructs and statistics, and are more institutional in their characterization of problems and recommendations for further action.For the most part, the ethnographic method is qualitative, participa-tory, detailed, and quite comprehensive in characterizing key variables as the researcher found them on the ground. This differs slightly from urban planning’s preoccupation with public policy, policy analysis, rules and regulations, institutionalized procedures, the public good, and overall positivist and rationalist concerns with documenting reality and helping to lead transformative planning processes, whether in the realm of land use, transportation, housing, economic development, infrastructure, or the environment. Although International Urban Planning was to be taught in a rather orthodox manner with recourse to understanding planning cultures, best practices, lessons learned, and implications for similar situations, the Global Urbanism and Culture course was slightly more aligned with the discussions put forward by Low. These included attention to postmodern ideals, the use of creativity in community planning, distinctions between popular and highbrow culture, and the building of iconic structures in contexts of urban regeneration and mega-event planning. As such, my students were somewhat already exposed to issues of embodied spaces and to ideas of... (shrink)

Whatever its ultimate philosophical merits, it is often thought that the growing block theory presents an intuitive picture of reality that accords well with our pre-reflective or folk view of time, and of the past, present, and future. This is partly motivated by the idea that we find it intuitive that, in some sense, the future is open and the past closed, and that the growing block theory is particularly well suited to accommodate this being so. In this paper, we (...) empirically investigate three claims. First, that people's intuitive or pre-reflective sense that the future is open is at least partly captured by there being truth-gaps for future contingents: what we call alethic openness. Second, that people, perhaps tacitly, believe that the fact that the future is alethically open is a reason to endorse the growing block theory; and third, that part of what explains why people tend to naively represent our world as a growing block is that they represent the future as alethically open. We found evidence in support of the first two claims. We consider the implications of these findings for several debates in the philosophy of time. (shrink)

Present-bias is the preference, all else being equal, for positive events to be located in the present rather than the non-present, and for negative events to be located in the non-present rather than the present. Very little attention has been given to present-bias in the contemporary literature on time biases. This may be because it is often assumed that present-bias is not a distinctive psychological kind; that what explains people’s being present-biased is just what explains them displaying various other time-biases. (...) According to this view, there is no need to investigate present-bias independently of investigating these other biases, since present-bias is really just a manifestation of these other biases. We call this the manifestation thesis. We take up the question of whether the manifestation thesis is true, and argue that it is not. Thus, by failing to investigate present-bias in its own right we are failing fully to understand the spectrum of ways in which people display time biases. In turn, we suggest, this may have implications for the ways we evaluate whether present-bias is rationally permissible. (shrink)

There is a virtual consensus among commentators on Descartes that the causal principle by which he relates the objective reality of his ideas to the formal reality of their causes isindefensible. In particular, Descartes’ claim that this principle follows from the general principle which states that the cause must contain at least as much reality as the effect has been examined and rejected as logically implausible. I challenge this view by showing that there is a logically plausible derivation of the (...) causal principle of ideas from the general causal principle. This result has important implications due to the crucial role the causal principle of ideas plays in Descartes’ first a posteriori argument for the existence of God. (shrink)

There is a virtual consensus among commentators on Descartes that the causal principle by which he relates the objective reality of his ideas to the formal reality of their causes isindefensible. In particular, Descartes’ claim that this principle follows from the general principle which states that the cause must contain at least as much reality as the effect has been examined and rejected as logically implausible. I challenge this view by showing that there is a logically plausible derivation of the (...) causal principle of ideas from the general causal principle. This result has important implications due to the crucial role the causal principle of ideas plays in Descartes’ first a posteriori argument for the existence of God. (shrink)

OF all the things that Plato was, he was primarily a philosopher and a metaphysician. Should this statement seem merely to emphasize the obvious; then let us explain why so simple a statement should rate special mention. There have always been those who are too willing to look upon the author of the ‘Theory of Ideas’ as an artist, a mystic, a poet but not a metaphysician. In this view, Plato’s Ideas are understandable only through the analysis of the personality (...) of an artist; it is a view which interjects far too much of the subjective into what must be seen as the objective ground for his whole philosophy. The possibility of such conflicting views on Plato can be explained by the fact that nowhere does Plato present in his writings a truly definitive Theory of Ideas and a workable proof for them. Some like Stewart require the assistance of psychology to examine Plato. Fite, on a priori grounds, makes a feeble attempt to take Plato out of the realm of any metaphysics whatsoever. Grote confuses reason and myth until nothing remains of Plato but a kind of mixed-up jumble. Others, of course, are loyal to the commitments of a critic and endeavour to discover the meaning of Plato and to present it fairly and honestly. (shrink)

As basic as epistemological questions might be, they all depend upon a far more fundamental question, which must be faced squarely, if a man is to be ever really sure. That question is simply stated: ‘What is knowing?’ So basic is it, indeed, that only when the answer is forthcoming will those phantoms of validity and truth, of certitude and synthesis, be dissolved once and for all.

Faces provide information about a person's identity, as well as their sex, age, and ethnicity. People also infer social and personality traits from the face — judgments that can have important societal and personal consequences. In recent years, deep convolutional neural networks (DCNNs) have proven adept at representing the identity of a face from images that vary widely in viewpoint, illumination, expression, and appearance. These algorithms are modeled on the primate visual cortex and consist of multiple processing layers of simulated (...) neurons. Here, we examined whether a DCNN trained for face identification also retains a representation of the information in faces that supports social‐trait inferences. Participants rated male and female faces on a diverse set of 18 personality traits. Linear classifiers were trained with cross validation to predict human‐assigned trait ratings from the 512 dimensional representations of faces that emerged at the top‐layer of a DCNN trained for face identification. The network was trained with 494,414 images of 10,575 identities and consisted of seven layers and 19.8 million parameters. The top‐level DCNN features produced by the network predicted the human‐assigned social trait profiles with good accuracy. Human‐assigned ratings for the individual traits were also predicted accurately. We conclude that the face representations that emerge from DCNNs retain facial information that goes beyond the strict limits of their training. (shrink)

Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghanistan. TG continues intensive daily rehabilitation, which recently included the integration of physical therapy (PT) with neuromodulation using translingual neurostimulation (TLNS) to facilitate neuroplasticity. Recent findings with PT+TLNS demonstrated that recovery of motor function occurred (...) beyond conventional time limits, currently extending past 14-years post-injury. To investigate whether PT+TLNS similarly resulted in associated cognitive function improvements, we examined event-related potentials (ERPs) with the brain vital signs framework. In parallel with motor function improvements, brain vital signs detected significant increases in basic attention (as measured by P300 response amplitude) and cognitive processing (as measured by contextual N400 response amplitude). These objective cognitive improvements corresponded with TG’s self-reported improvements, including a noteworthy and consistent reduction in ongoing symptoms of post-traumatic stress disorder (PTSD). The findings provide valuable insight into the potential importance of non-invasive neuromodulation in cognitive rehabilitation, in addition to initial indications for physical rehabilitation. (shrink)

The faces of both adults and children can be classified accurately by sex, even in the absence of sex‐stereotyped social cues such as hair and clothing (Wild et al., 2000). Although much is known from psychological and computational studies about the information that supports sex classification for adults' faces, children's faces have been much less studied. The purpose of the present study was to quantify and compare the information available in adults' versus children's faces for sex classification and to test (...) alternative theories of how human observers distinguish male and female faces for these different age groups. We implemented four computational/neural network models of this task that differed in terms of the age categories from which the sex classification features were derived. Two of the four strategies replicated the advantage for classifying adults' faces found in previous work. To determine which of these strategies was a better model of human performance, we compared the performance of the two models with that of human subjects at the level of individual faces. The results suggest that humans judge the sex of adults' and children's faces using feature sets derived from the appropriate face age category, rather than applying features derived from another age category or from a combination of age categories. (shrink)

The faces of both adults and children can be classified accurately by sex, even in the absence of sex‐stereotyped social cues such as hair and clothing (Wild et al., 2000). Although much is known from psychological and computational studies about the information that supports sex classification for adults' faces, children's faces have been much less studied. The purpose of the present study was to quantify and compare the information available in adults' versus children's faces for sex classification and to test (...) alternative theories of how human observers distinguish male and female faces for these different age groups. We implemented four computational/neural network models of this task that differed in terms of the age categories from which the sex classification features were derived. Two of the four strategies replicated the advantage for classifying adults' faces found in previous work. To determine which of these strategies was a better model of human performance, we compared the performance of the two models with that of human subjects at the level of individual faces. The results suggest that humans judge the sex of adults' and children's faces using feature sets derived from the appropriate face age category, rather than applying features derived from another age category or from a combination of age categories. (shrink)

Presents Bernard Lonergan's five "verbum" articles that originally appeared in Theological studies. For Thomist students and scholars this "verbum" study offers a careful appraisal of the Thomist theory of knowledge as well as an introduction to the concepts found in Father Lonergan's "Insight". Since the concept of "verbum" dynamically affects the thought of Aquinas, it is necessary to grasp this concept to understand Thomist metaphysics and rational psychology. Lonergan has carefully analyzed and explicitly outlined "verbum"--An integral part of the Thomist (...) theory of knowledge. "Verbum" is examined as a tool of definition and for its impact on understanding, logical thought procession and related ideas stemming from "verbum". Discusses "the word" and its relation to abstraction. Focusses on St. Thomas' immediate concern in finding in Aristotle the point of insertion for Augustinian thought and in fusing a phenomenology of the subject with a psychology of the soul. (shrink)

This collection of recent articles by leading scholars is designed to illuminate one of the greatest and most influential philosophical books of all time. It includes incisive commentary on every major theme and argument in the Meditations, and will be valuable not only to philosophers but to historians, theologians, literary scholars, and interested general readers.

People recognize faces of their own race more accurately than faces of other races. The “contact” hypothesis suggests that this “other‐race effect” occurs as a result of the greater experience we have with own‐ versus other‐race faces. The computational mechanisms that may underlie different versions of the contact hypothesis were explored in this study. We replicated the other‐race effect with human participants and evaluated four classes of computational face recognition algorithms for the presence of an other‐race effect. Consistent with the (...) predictions of a developmental contact hypothesis, “experience‐based models” demonstrated an other‐race effect only when the representational system was developed through experience that warped the perceptual space in a way that was sensitive to the overall structure of the model's experience with faces of different races. When the model's representation relied on a feature set optimized to encode the information in the learned faces, experience‐based algorithms recognized minority‐race faces more accurately than majority‐race faces. The results suggest a developmental learning process that warps the perceptual space to enhance the encoding of distinctions relevant for own‐race faces. This feature space limits the quality of face representations for other‐race faces. (shrink)

Creativity is the hallmark of human intelligence. Roli et al. (Frontiers in Ecology and Evolution 9:806283, 2022) state that algorithms cannot achieve human creativity. This paper analyzes cooperation between humans and intelligent algorithmic tools to compensate for algorithms’ limited creativity. The intelligent tools have functionality from the neocortex, the brain’s center for learning, reasoning, planning, and language. The analysis provides four key insights about human-tool cooperation to solve challenging problems. First, no neocortex-based tool without feelings can achieve human creativity. Second, (...) an interactive tool exploring users’ feeling-guided creativity enhances the ability to solve complex problems. Third, user-led abductive reasoning incorporating human creativity is essential to human-tool cooperative problem-solving. Fourth, although stakeholders must take moral responsibility for the adverse impact of tool answers, it is still essential to teach tools moral values to generate trustworthy answers. The analysis concludes that the scientific community should create neocortex-based tools to augment human creativity and enhance problem-solving rather than creating autonomous algorithmic entities with independent but less creative problem-solving. (shrink)

The idea that gauge theory has `surplus' structure poses a puzzle: in one much discussed sense, this structure is redundant; but on the other hand, it is also widely held to play an essential role in the theory. In this paper, we employ category-theoretic tools to illuminate an aspect of this puzzle. We precisify what is meant by `surplus' structure by means of functorial comparisons with equivalence classes of gauge fields, and then show that such structure is essential for any (...) theory that represents a rich collection of physically relevant fields which are `local' in nature. (shrink)

A fundamental discussion in lower-level undergraduate neuroscience and psychology courses is Descartes’s “radical” or “mind-body” dualism. According to Descartes, our thinking mind, the res cogitans, is separate from the body as physical matter or substance, the res extensa. Since the transmission of sensory stimuli from the body to the mind is a physical capacity shared with animals, it can be confused, misled, or uncertain (e.g., bodily senses imply that ice and water are different substances). True certainty thus arises from within (...) the mind and its capacity to doubt physical stimuli. Since this doubting mind is a thinking thing that is distinct from bodily stimuli, truth and certainty are reached through the doubting mind as cogito ergo sum, or the certainty of itself as it thinks: hence Descartes’s famous maxim, I think, therefore I am. However, in the last century of Western philosophy, with nervous system investigation, and with recent advances in neuroscience, the potential avenues to explore student’s understanding of the epistemology and effects of Cartesian mind-body dualism has expanded. This article further explores this expansion, highlighting pedagogical practices and tools instructors can use to enhance a psychology student’s understanding of Cartesian dualistic epistemology, in order to think more critically about its implicit assumptions and effects on learning. It does so in two ways: first, by offering instructors an alternative philosophical perspective to dualistic thinking: a mind-body holism that is antithetical to the assumed binaries of dualistic epistemology. Second, it supplements this philosophical argument with a practical component: simple mind-body illusions that instructors may use to demonstrate contrary epistemologies to students. Combining these short philosophical and neuroscience arguments thereby acts as a pedagogical tool to open new conceptual spaces within which learning may occur. (shrink)

Default logic has been a very active research topic in artificial intelligence since the early 1980s, but has not received as much attention in the philosophical literature thus far. This paper shows one way in which the technical tools of artificial intelligence can be applied in contemporary epistemology by modeling a paradigmatic case of deep disagreement using default logic. In §1 model-building viewed as a kind of philosophical progress is briefly motivated, while §2 introduces the case of deep disagreement we (...) aim to model. On the heels of this, §3 defines our formal framework, viz., a refined Horty-style default logic. §4 then uses the framework to model deep disagreement, and finally §5 provides a critical discussion of the result. (shrink)

Bio-ontologies are essential tools for accessing and analyzing the rapidly growing pool of plant genomic and phenomic data. Ontologies provide structured vocabularies to support consistent aggregation of data and a semantic framework for automated analyses and reasoning. They are a key component of the Semantic Web. This paper provides background on what bio-ontologies are, why they are relevant to botany, and the principles of ontology development. It includes an overview of ontologies and related resources that are relevant to plant science, (...) with a detailed description of the Plant Ontology (PO). We discuss the challenges of building an ontology that covers all green plants (Viridiplantae). Key results: Ontologies can advance plant science in four keys areas: 1. comparative genetics, genomics, phenomics, and development, 2. taxonomy and systematics, 3. semantic applications and 4. education. Conclusions: Bio-ontologies offer a flexible framework for comparative plant biology, based on common botanical understanding. As genomic and phenomic data become available for more species, we anticipate that the annotation of data with ontology terms will become less centralized, while at the same time, the need for cross-species queries will become more common, causing more researchers in plant science to turn to ontologies. (shrink)

This major publication is a history of the semantic tradition in philosophy from the early nineteenth century through its incarnation in the work of the Vienna Circle, the group of logical positivists that emerged in the years 1925–1935 in Vienna who were characterised by a strong commitment to empiricism, a high regard for science, and a conviction that modern logic is the primary tool of analytic philosophy. In the first part of the book, Alberto Coffa traces the roots of logical (...) positivism in a semantic tradition that arose in opposition to Kant's theory that a priori knowledge is based on pure intuition and the constitutive powers of the mind. In Part II, Coffa chronicles the development of this tradition by members and associates of the Vienna Circle. Much of Coffa's analysis draws on the unpublished notes and correspondence of many philosophers. The book, however, is not merely a history of the semantic tradition from Kant 'to the Vienna Station'. Coffa also critically reassesses the role of semantic notions in understanding the ground of a priori knowledge and its relation to empirical knowledge and questions the turn the tradition has taken since Vienna. (shrink)

For over 40 years, J. I. Packer's classic has been an important tool to help Christians around the world discover the wonder, the glory and the joy of knowing God. Explaining both who God is and how we can relate to him, this thought-provoking work seeks to transform and enrich the Christian understanding of God.

This paper develops a general language of event configurations to discuss and compare various modes of proposition formation. It is shown that any finite orthogonality space can be numerically encoded. This encoding is applied to show that the quasimanual of all orthogonal subsets of any finite point-determining orthogonality space may be decomposed into a union of manuals and that the logic of these quasimanuals may be regarded as a composite of interlocking associative orthoalgebras.

Consequence is at the heart of logic, and an account of consequence offers a vital tool in the evaluation of arguments. This text presents what the authors term as 'logical pluralism' arguing that the notion of logical consequence doesn't pin down one deductive consequence relation; it allows for many of them.

It is proposed that symmetry of stone tools may derive from perceptual similarity rather than from cognitively more complex awareness of symmetry. Although encodement of shapes necessarily involves symmetry (as evidenced by the confusability of enantiomorphs), it does not imply awareness of symmetry. Responses of relatively simple organisms, such as bees, support the notion that the processes involved are likely to be perceptual.

Purpose: This conceptual-epistemological paper deals with the old problem of inversion of thinking, as typified by traditional metaphysics-ontology. It is proposed that a thorough constructivism -- which views structures of mind, nature, and all, as not derived from (not referring to) any pre-structured given mind-independent reality (zero-derivation, 0-D) -- can go beyond this conceptual impasse; it can also serve as a fall-back position for positive ontologies. Practical implications: The practical result of 0-D is that all structures of experience are understood (...) as tools serving individual and collective subjects. Conclusion: This conceptual correction results in a simplification for the understanding of some conceptual puzzles, such as the mind-brain relation, but also in a considerable increase of responsibility, because entities and agents formerly considered responsible, and outside the mind, are recognized to be extensions of the subjects. (shrink)

This work addresses scientism and relativism, two false philosophies that divorce science from culture in general and from tradition in particular. It helps break the isolation of science from the rest of culture by promoting popular science and reasonable history of science. It provides examples of the value of science to culture, discussions of items of the general culture, practical strategies and tools, and case studies. It is for practising professionals, political scientists and science policy students and administrators.